Upstream regulators of phosphoinositide 3-kinase and their role in diseases |
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| Authors: | Dandan Wang Weijie Zhou Jingyu Chen Wei Wei |
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| Affiliation: | 1. Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China;2. Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei, China;3. Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China |
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| Abstract: | Phosphoinositide 3-kinase (PI3K), a crucial signaling molecule, is regulated by various upstream regulators. Traditionally, receptor tyrosine kinases and G protein-coupled receptor are regarded as its principle upstream regulators; however, recent reports have indicated that spleen tyrosine kinase, β-arrestin2, Janus kinase, and RAS can also perform this role. Dysregulation of PI3K is common in the progression of various diseases, including, but not limited to, tumors, Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, and acute myelogenous leukemia. The aim of this review is to provide a perspective on PI3K-related diseases examining both the classical and nonclassical upstream regulators of PI3K in detail. |
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| Keywords: | diseases PI3K regulators signaling pathway |
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