Fusobacterium nucleatum and colorectal cancer: A mechanistic overview |
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| Authors: | Nasser Hashemi Goradel Siamak Heidarzadeh Samira Jahangiri Bagher Farhood Keywan Mortezaee Neda Khanlarkhani Babak Negahdari |
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| Institution: | 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Microbiology and Virology, Zanjan University of Medical Sciences, Zanjan, Iran;3. Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;4. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran;5. Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;6. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Colorectal cancer (CRC) is the third most prevalent cancer in the world. There are many risk factors involved in CRC. According to recent findings, the tumor microenvironment and feces samples of patients with CRC are enriched by Fusobacterium nucleatum. Thus, F. nucleatum is proposed as one of the risk factors in the initiation and progression of CRC. The most important mechanisms of Fusobacterium nucleatum involved in CRC carcinogenesis are immune modulation (such as increasing myeloid-derived suppressor cells and inhibitory receptors of natural killer cells), virulence factors (such as FadA and Fap2), microRNAs (such as miR-21), and bacteria metabolism. The aim of this review was to evaluate the mechanisms underlying the action of F. nucleatum in CRC. |
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| Keywords: | carcinogenesis colorectal cancer (CRC) Fusobacterium nucleatum tumor microenvironment |
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