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Ulysses - an application for the projection of molecular interactions across species |
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| Authors: | Danielle?Kemmer Yong?Huang Sohrab?P?Shah Jonathan?Lim Jochen?Brumm Macaire?MS?Yuen John?Ling Tao?Xu |
| Institution: | (1) Center for Genomics and Bioinformatics, Karolinska Institutet, 171 77 Stockholm, Sweden;(2) Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z 4H4, BC, Canada;(3) UBC Bioinformatics Centre, University of British Columbia, Vancouver, V6T 1Z4, BC, Canada;(4) Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada;(5) Michael Smith Laboratories, University of British Columbia, Vancouver, V6T 1Z4, BC, Canada;(6) Department of Computer Science, University of British Columbia, Vancouver, V6T 1Z4, BC, Canada |
| Abstract: | We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interactions detected in various species. Ulysses was designed to perform such Interolog Analysis by the projection of model organism interaction data onto homologous human proteins, and thus serves as an accelerator for the analysis of uncharacterized human proteins. The relevance of projections was assessed and validated against published reference collections. All source code is freely available, and the Ulysses system can be accessed via a web interface . |
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