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Effects of dalargin on the processes of cell division in the gastric epithelium during stress
Authors:S S Timoshin  S I Shvets  N B Murzina  G P Berezina
Abstract:Influence of dalargine on cell division in stomach epithelium of male rats, stressed by 4-hour immobilization was studied using autoradiographic 3H-thymidine test. Norepinephrine and diene conjugates content in stomach tissue were also determined in these animals spectrofluorometrically. Dalargine (10 micrograms/kg) gas injected to experimental group 40 min before stressing. Dalargine prevented stress-induced DNA-synthesis disturbances and stabilized proliferating cells pool just after the stress. It also decreased proliferation processes depression in 12 and 24 hours after stress and accelerated compensatory DNA-synthesis.
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