| 急性白血病患者骨髓组织血管新生与Bcl-2蛋白关系的研究 |
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| 引用本文： | 周燕,何广胜,单学赟,王纯斌,孙乃同,邵钰,唐云龙.急性白血病患者骨髓组织血管新生与Bcl-2蛋白关系的研究[J].生物磁学,2013(3):512-514. |
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| 作者姓名： | 周燕 何广胜 单学赟 王纯斌 孙乃同 邵钰 唐云龙 |
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| 作者单位： | [1]江苏省盐城市第三人民医院血液科,江苏盐城224000 [2]苏州大学附属第一人民医院血液科,江苏苏州215006 |
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| 摘 要： | 目的：探讨急性白血病患者骨髓组织血管新生与Bcl-2蛋白的关系,为临床治疗白血病提供可靠的理论依据。方法：回顾性分析2007年3月～2011月6月我院收治的42例急性白血病患者和42例增生性贫血和疑为血液系统疾病的患者作为对照组的临床资料。结果：对照组患者骨髓组织中的微血管密度（MVD）、血管内皮生长因子（VEGF）及Bcl-2蛋白的表达水平均显著低于急性白血病患者,两组比较差异有极显著统计学意义（P〈0.01）。急性白血病患者骨髓组织中VEGF、MVD及Bcl-2蛋白之间,彼此两两呈正相关性。结论：Bcl-2蛋白的阳性表达在白血病的抗凋亡与血管新生方面,都发挥着重要的作用,通过对Bcl-2蛋白的研究,为临床治疗白血病提供了一条诊断、治疗白血病的新思路。
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| 关 键 词： | 急性白血病 骨髓组织 血管新生 Bcl-2 |
Research on the Relationship between Bone Marrow Angiogenesis and Bcl-2 in Acute Leukemia |
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| ZHOU Yan,HE Guang-sheng,SHAN Xue-yun,WANG Chun-bin,SUN Nai-tong,SHAO Yu,TANG Yun-long.Research on the Relationship between Bone Marrow Angiogenesis and Bcl-2 in Acute Leukemia[J].Biomagnetism,2013(3):512-514. |
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| Authors: | ZHOU Yan HE Guang-sheng SHAN Xue-yun WANG Chun-bin SUN Nai-tong SHAO Yu TANG Yun-long |
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| Institution: | 1 Department of Hematology, Third People＇s hospital of Yancheng, Yancheng, Jiangsu, 224000, China;2 Department of Hematology, the First people＇s Hospital Affiliated to Suzhou University, Suzhou, Jiangsu, 215006, China) |
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| Abstract: | Objective： To investigate the relationship between bone marrow angiogenesis and bcl-2 in acute leukemia. Methods： Retrospective analysis of clinical data of 2011 June, 42 patients with acute leukemia in March 2007. Results： MVD, the expression of VEGF and Bcl-2 in bone marrow tissue of control group were significantly lower than those patients with acute leukemia（P〈0.01）. Between VEGF, MVD and the expression of Bcl-2 protein in acute leukemia patients and bone marrow tissue, two of each other two were positively correlated. Conclusion： Positive expression of Bcl-2 protein in leukemia anti-apoptosis and angiogenesis, plays an important role, through Bcl-2 protein for the clinical treatment of leukemia, a diagnosis, new ideas for the treatment of leukemia. |
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| Keywords: | Acute leukemia Bone marrow Angiogenesis Bcl-2 |
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