| 新型冠状病毒SARS-CoV-2检测技术的研究进展 |
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| 引用本文： | 张晓元,张艳艳,张小刚,刘霞,陈勉,刘飞,张岱州,凌沛学.新型冠状病毒SARS-CoV-2检测技术的研究进展[J].生物化学与生物物理进展,2020,47(4):275-285. |
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| 作者姓名： | 张晓元 张艳艳 张小刚 刘霞 陈勉 刘飞 张岱州 凌沛学 |
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| 作者单位： | 1)山东省药学科学院,山东省生物药物重点实验室,山东省多糖类药物工程实验室, 多糖类药物发酵与精制国家地方联合工程实验室,博士后科研工作站,济南 250101,1)山东省药学科学院,山东省生物药物重点实验室,山东省多糖类药物工程实验室, 多糖类药物发酵与精制国家地方联合工程实验室,博士后科研工作站,济南 250101,1)山东省药学科学院,山东省生物药物重点实验室,山东省多糖类药物工程实验室, 多糖类药物发酵与精制国家地方联合工程实验室,博士后科研工作站,济南 250101,1)山东省药学科学院,山东省生物药物重点实验室,山东省多糖类药物工程实验室, 多糖类药物发酵与精制国家地方联合工程实验室,博士后科研工作站,济南 250101,1)山东省药学科学院,山东省生物药物重点实验室,山东省多糖类药物工程实验室, 多糖类药物发酵与精制国家地方联合工程实验室,博士后科研工作站,济南 250101,1)山东省药学科学院,山东省生物药物重点实验室,山东省多糖类药物工程实验室, 多糖类药物发酵与精制国家地方联合工程实验室,博士后科研工作站,济南 250101;2)山东福瑞达医药集团有限公司,济南 250101,1)山东省药学科学院,山东省生物药物重点实验室,山东省多糖类药物工程实验室, 多糖类药物发酵与精制国家地方联合工程实验室,博士后科研工作站,济南 250101,1)山东省药学科学院,山东省生物药物重点实验室,山东省多糖类药物工程实验室, 多糖类药物发酵与精制国家地方联合工程实验室,博士后科研工作站,济南 250101;2)山东福瑞达医药集团有限公司,济南 250101 |
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| 基金项目： | 山东省重点研发计划（2019GSF107040）和济南市高校院所创新团队项目（2019GXRC038）资助. |
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| 摘 要： | 新型冠状病毒(SARS-CoV-2)具有较强的传播能力,已证实可人传人,无症状携带者也可传播.快速、准确诊断新型冠状病毒对控制疫情爆发尤为重要.论文基于国内外的相关研究进展,就新型冠状病毒的荧光PCR、等温扩增、基于Cas酶技术、免疫法四大类检测技术进行了详细的分析与梳理,以期为新型冠状病毒及其他流行性病毒诊断及防控提供借鉴和思路.
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| 关 键 词： | 新型冠状病毒 核酸检测 免疫检测 聚合酶链式扩增 反转录 |
| 收稿时间： | 2020/3/11 0:00:00 |
| 修稿时间： | 2020/3/31 0:00:00 |
Research Progress of New Coronavirus SARS-CoV-2 Detection Technology |
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| ZHANG Xiao-Yuan,ZHANG Yan-Yan,ZHANG Xiao-Gang,LIU Xi,CHEN Mian,LIU Fei,ZHANG Dai-Zhou and LING Pei-Xue.Research Progress of New Coronavirus SARS-CoV-2 Detection Technology[J].Progress In Biochemistry and Biophysics,2020,47(4):275-285. |
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| Authors: | ZHANG Xiao-Yuan ZHANG Yan-Yan ZHANG Xiao-Gang LIU Xi CHEN Mian LIU Fei ZHANG Dai-Zhou and LING Pei-Xue |
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| Institution: | 1)Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide drugs, Postdoctoral Scientific Research Workstation, Jinan 250101, China,1)Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide drugs, Postdoctoral Scientific Research Workstation, Jinan 250101, China,1)Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide drugs, Postdoctoral Scientific Research Workstation, Jinan 250101, China,1)Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide drugs, Postdoctoral Scientific Research Workstation, Jinan 250101, China,1)Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide drugs, Postdoctoral Scientific Research Workstation, Jinan 250101, China,1)Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide drugs, Postdoctoral Scientific Research Workstation, Jinan 250101, China; 2)Shandong Freda Pharmaceutical Group Company, Jinan 250101, China,1)Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide drugs, Postdoctoral Scientific Research Workstation, Jinan 250101, China,1)Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide drugs, Postdoctoral Scientific Research Workstation, Jinan 250101, China; 2)Shandong Freda Pharmaceutical Group Company, Jinan 250101, China |
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| Abstract: | The new coronavirus SARS-CoV-2 has a strong transmission ability and has been confirmed to be transmissible from person to person. Asymptomatic carriers can also be a source of transmission. Rapid and accurate diagnosis of the new coronavirus is particularly important to control the outbreak. Based on the relevant research progress at home and abroad, this paper analyzes and combs the four major detection technologies of new coronaviruses such as fluorescent PCR, isothermal amplification, Cas enzyme technology and immunoassay, in order to provide references and ideas for the diagnosis, prevention and control of new coronaviruses and other epidemic viruses. |
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