Interaction of the pyridoindole stobadine with alkoxyl and stable free radicals |
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| Authors: | L Horakova R J Schaur P Balgavy G Egger |
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| Institution: | 1. Institute of Biochemistry, University of Graz, Graz, Austria;2. Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic;3. Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic;4. Institute of General and Experimental Pathology, University of Graz, Graz, Austria |
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| Abstract: | Stobadine, a pyridoindole derivative which has been synthesized in search of new antiarrhytmic drugs, was able to interact with alpha-diphenyl-beta-picrylhydrazyl (DPPH.) a stable free radical. Its scavenging potential was in the same order of magnitude as that of well known strong antioxidants. The scavenging effect of antioxidants tested increased in the order: stobadine, ascorbic acid, trolox, cysteine. Stobadine exerted a scavenging effect also towards alkoxyl radicals in a nonpolar solvent in the canthaxantin bleaching test. In this test stobadine was more effective than trolox. |
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