Increases in serum concentration of human heart-type fatty acid-binding protein following elective coronary intervention |
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| Authors: | Eftihia Sbarouni Panagiota Georgiadou Ioannis Sklavainas Antigoni Chaidaroglou Demosthenes Panagiotakos Demitrios Degiannis |
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| Institution: | 1. Second Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greeceesbarouni@yahoo.gr;3. Second Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece;4. Molecular Immunopathology and Histocompatibility Laboratory, Onassis Cardiac Surgery Center, Athens, Greece |
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| Abstract: | Background: Heart-type fatty acid-binding protein (H-FABP) is considered a marker of myocardial necrosis but whether or not it is modified by myocardial ischemia is not clear. We sought to investigate if H-FABP serum levels increase following non-urgent coronary angioplasty.Methods: We studied 31 patients undergoing coronary angioplasty. Peripheral venous samples were drawn immediately before angioplasty, 1?h after the first balloon inflation and 24?h after the procedure and assayed for H-FABP.Results: Serum levels of H-FABP increased significantly at 1?h vs baseline from 2554?±?1268 to 3322?±?245?pg?ml?1 (p?=?0.024). However, no differences were observed between 1?h and 24?h after angioplasty (3268?±?1861 vs 3322?±?2459?pg ml?1, p?=?0.87). Moreover, no significant difference was observed when we compared 24?h after angioplasty with the baseline (3268?±?1861vs 2554?±?1268?pg ml?1, p?=?0.112).Conclusions: We conclude that H-FABP significantly increases after elective coronary angioplasty at 1?h compared with baseline values; whether or not this has any prognostic significance for future events, as it occurs with troponins, needs to be studied further. |
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| Keywords: | Biomarkers heart-type fatty acids angioplasty |
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