Detection of microbial surface antigens that bind Lewis<sup><nobr>a</nobr></sup> antigen期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Detection of microbial surface antigens that bind Lewis^a antigen

Authors:	SD Essery DM Weir VS James CC Blackwell AT Saadi A Busuttil G Tzanakaki

Institution:	Department of Medical Microbiology, University Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK;Department of Forensic Medicine Unit, University Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK;Department of Microbiology, Hellenic Institute Pasteur, Athens, Greece

Abstract:	Abstract There is evidence that the Lewis^a blood group antigen is one of the receptors for a number of potentially pathogenic microorganisms. To determine how widely distributed the microbial adhesins are that bind this antigen, anti-idiotypic antibodies produced against monoclonal anti-Lewis^a were used in coagglutination assays to screen a variety of species. The following were agglutinated: 7/7 strains of Staphylococcus aureus ; 10/19 (53%) strains of Neisseria meningitidis ; 8/13 (62%) strains of Haemophilus influenzae ; 1/3 strains of Helicobacter pylori ; 1/2 strains of Neisseria gonorrhoeae ; 1/2 strains of Candida albicans . The application of the anti-idiotypic antibodies to studies of host cell receptors, isolation of adhesins and development of new epidemiological typing reagents is discussed.

Keywords:	Staphylococcus aureus Neisseria meningitidis Haemophilus influenzae Candida albicans Helicobacter pylori Lewis^a antigen Antiidiotypic antibodies