A pair of new sesquiterpene isomers containing spiro heterocyclic skeleton from plant-derived fungus Botryosphaeria dothidea |
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| Institution: | 1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. College of Life Sciences, Inner Mongolia Agricultural University, Hohhot 010018, PR China;3. College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR China;4. Inner Mongolia Grand Pharmaceutical Co., Ltd, Hohhot 010010, PR China;1. UMR 152 PharmaDev, Université de Toulouse, IRD, UPS, Toulouse, France;2. Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru;3. Institut de Chimie de Toulouse, ICT UAR 2599, Université Paul Sabatier-Toulouse III, Toulouse, France;1. Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;3. Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, 51097 Reims, France;4. Food Science, Department of Chemistry, Carleton University, Room 207D Steacie Building, 1125 Colonel by Drive, K1S 5B6 Ottawa, Canada;1. Department of Pharmacology, Basic Medical School of Yangtze University, Jingzhou, Hubei Province, China;2. Department of Pathology and Physiology, Basic Medical School of Yangtze University, Jingzhou, Hubei Province, China;3. Narula Research, Chapel Hill, 27516 NC, USA;4. Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea |
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| Abstract: | A pair of new sesquiterpene isomers containing a spiro heterocyclic skeleton, dothimes A (1) and B (2), together with six known compounds, quindoline (3), (S)-3-(3-indolyl)lactic acid methyl ester (4), dankasterone B (5), dibutyl phthalate (6), (1S,3R,4R,7S)-3,4-dihydroxy-α-bisabolol (7), and p-hydroxybenzaldehyde (8), were isolated from the plant-derived fungus Botryosphaeria dothidea. The structures of all isolated compounds were determined based on extensive spectroscopic analyses, including 1D/2D nuclear magnetic resonance (NMR), and high resolution electrospray ionization mass spectrometry (HRESIMS) data, as well as by comparison with literature reports. Compounds 1 and 2 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 63.66 and 58.29 μM, respectively. |
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| Keywords: | Sesquiterpene Anti-inflammatory activity Nitric oxide release |
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