C19-Diterpenoid alkaloids from Aconitum richardsonianum |
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| Institution: | 1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, People''s Republic of China;2. Affiliated Hospital of Southwest Jiaotong University ＆ The Third People Hospital of Chengdu, Chengdu 610031, Sichuan, People''s Republic of China;3. Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, People''s Republic of China;1. Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh City, Viet Nam;2. Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam;3. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;4. Department of Biological Resources, Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam;1. Hunan Province Cooperative innovation Center for Molecular Target New Drug Study, the Key Laboratory of Environment and Critical Human Diseases Prevention of the Education Department of Hunan Province, Hengyang Medical School, University of South China, Hengyang 421001, China;2. College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China;3. South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;1. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;2. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;3. Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;4. Thai Nguyen University of Agriculture and Forestry, Quyet Thang, Thai Nguyen 24119, Viet Nam;1. Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, and State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;2. School of Life Sciences, Yunnan University, Kunming 650500, People’s Republic of China;3. Yuxi Cigarette Factory, Hongta Tobacco Group Co., Ltd., Yuxi 653100, People’s Republic of China;1. Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China;2. College of Pharmacy, Dali University, Dali 671000, China;1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam;2. Institute of Biotechnology, VAST, Hanoi, Vietnam |
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| Abstract: | Three new aconitine-type C19-diterpenoid alkaloids, richardsonines A-C (1–3), were isolated from the roots of Aconitum richardsonianum Lauener, together with seventeen known compounds (4–20). Their structures were elucidated by extensive spectroscopic analysis, and the absolute stereochemistry of 1 was confirmed by X-ray crystallography. Compounds 2, 5, 8 and 9 were rare C19-diterpenoid alkaloids bearing an OH group at C-16. Isolated compounds were evaluated for inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated neuroinflammatory responses in BV-2 microglial cells. Compounds 3 and 7 showed weak antineuroinflammatory effects with inhibition rates of 35.32 ± 2.29% and 39.94 ± 2.50%, respectively, at a concentration of 100 µM. |
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| Keywords: | Aconitum richardsonianum Lauener Ranunculaceae Diterpenoid alkaloids Anti-neuroinflammatory |
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