The association between microRNA polymorphisms and the risk of childhood acute lymphoblastic leukemia: A meta-analysis |
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| Institution: | 1. Student Research Committee, School of Medical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Medical Oncologist-Hematologist, Internal Medicine Department, Talaghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran;1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea;2. Department of Hematology and Medical Oncology, Kyung Hee University Hospital, School of Medicine, Kyun Hee University, Seoul, South Korea;3. Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea;1. Research Unit for General Practice, Aarhus, Bartholins Alle 2, 8000 Aarhus C, Denmark;2. Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200 Aarhus C, Denmark;1. Ontario Health (Cancer Care Ontario), 525 University Ave, Toronto, Ontario, Canada;2. Epidemiology & Biostatistics, Western University, London, Ontario, Canada;3. Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;4. Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada;5. Division of Medical Oncology & Hematology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;6. Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;7. Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada;1. Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, United States;2. Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, United States;1. Ascension Saint Francis Hospital, 355 Ridge Ave, Evanston, IL 60202, USA;2. MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;3. Texas Health Presbyterian Hospital Dallas, 8200 Walnut Hl Ln, Dallas, TX 75231, USA;1. Department of Medicine, Division of Digestive Diseases, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA;2. Department of Internal Medicine, The Wright Center for Graduate Medical Education, 501S. Washington Avenue, Scranton, PA 18505, USA;3. Geisinger Commonwealth School of Medicine, 525, Pine Street, Scranton, PA 18510, USA;4. Department of Surgery, Division of Orthopedics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA;5. Division of Hematology-Oncology, John H Stroger Jr Hospital of Cook County, 1950 W Polk St, Chicago, IL 60612, USA;6. Division Chief Gastroenterology, Upstate University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA;7. Division of Gastroenterology, Upstate University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA;8. Division of Gastroenterology, Hepatology and Nutrition, University of Texas, 6431, Fannin, Houston, TX 77030, USA;9. Mercer University School of Medicine Macon, GA 31207, USA |
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| Abstract: | The aim of this meta-analysis was to determine the relationship between microRNA polymorphisms and the risk of childhood acute lymphoblastic leukemia comprehensively. PubMed, EMBASE, Scopus, Web of Science, the Cochrane Library, Global Index Medicus, Clinicaltrials.gov, ProQuest, and Open Grey databases were used to find relevant papers. Using the STATA 16.0 and CMA 3.0 software, the significance of relationships between microRNA polymorphisms and childhood acute lymphoblastic leukemia risk was evaluated using odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for five genetic models. The results of the meta-analysis showed that there was no significant association between the polymorphism of miR-146a rs2910164 and childhood acute lymphoblastic leukemia risk in different genetic models. Also, in the sensitivity analysis, removing Xue's study from the analysis indicated that both the homozygote and recessive models are significantly affected. Additionally, there was a statistically significant relationship between the polymorphisms of pri-miR-34b/c rs4938723 (in the homozygote and recessive models) and miR-612 rs12803915 (in the allele and dominant models) and childhood acute lymphoblastic leukemia risk. These findings suggest that the rs4938723 and rs12803915 polymorphisms may have a role in the development of childhood acute lymphoblastic leukemia. |
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| Keywords: | Meta-analysis Childhood acute lymphoblastic leukemia MicroRNA Polymorphism Case-control study |
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