Effect modification of body mass index on the association between ovarian cysts and endometrial cancer |
| |
| Institution: | 1. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;2. Icahn School of Medicine at Mount Sinai, New York, NY, USA;3. Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy;4. Epidemiology and Biostatistics Unit, Istituto Nazionale dei Tumori IRCCS Fondazione “G.Pascale”, Napoli, Italy;5. Department of Epidemiology and Health Services Research, Center for Primary Care and Public Health (Unisantè), University of Lausanne, Lausanne, Switzerland;6. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy;7. Department of Humanities, Pegaso Online University, Naples, Italy;8. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA;1. Memorial Sloan Kettering Cancer Center, Department of Surgery, Urology Service, USA;2. VA New York Harbor Healthcare System, USA;3. New York University, Grossman School of Medicine, Department of Urology, USA;4. University of North Carolina, Department of Urology, Lineberger Comprehensive Cancer Center, USA;5. Department of Implementation Science, Wake Forest School of Medicine, USA;6. New York University, School of Global Public Health, Division of Global Health, USA;1. School of Women’s and Children’s Health, UNSW-Sydney, Australia;2. Centre for Primary Health Care and Equity, School of Population Health, UNSW-Sydney, Australia;3. Menzies Centre for Health Policy, School of Public Health, University of Sydney, Australia;4. Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, Australia;1. NHMRC Clinical Trials Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, New South Wales 2050, Australia;2. Centre for Health Research, University of Southern Queensland, Toowoomba, Queensland, Australia;3. Deakin Health Economics, School of Health and Social Development, Deakin University, Geelong, Victoria, Australia;4. Development Studies Discipline, Khulna University, Khulna 9208, Bangladesh;5. School of Social Sciences, Western Sydney University, Penrith Campus, New South Wales, Australia;6. The Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology Sydney, Ultimo, New South Wales 2007, Australia;1. Department of Cancer Strategy, Cancer Control Center, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka City, Osaka Prefecture 541-8567, Japan;2. Inequalities in Cancer Outcome Network, Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom;1. Macalester College, St. Paul, MN, United States;2. Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States;3. Program in Health Disparities Research, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN, United States;4. Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States;5. Brain Tumor Program, University of Minnesota, Minneapolis, MN, United States;1. Department of Surgery and Endoscopy, Tenwek Hospital, Bomet, Kenya;2. Department of Surgery, Alpert Medical School of Brown University, Providence, RI, USA;3. Biostatistics Branch, Division of Cancer and Epidemiology, National Cancer Institute, Rockville, MD, USA;4. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA;5. Department of Pathology, University of Nairobi, Nairobi, Kenya;6. Mayo Clinic, Rochester, MN, USA |
| |
| Abstract: | BackgroundOvarian cysts represent a common condition among women. Epidemiologic studies are inconsistent in determining if women with cysts are more likely to develop endometrial cancer (EC) regardless of overweight/obesity. We investigated the combined role of cysts and body mass index (BMI) on EC risk.MethodsWe pooled data from three case-control studies conducted in Italy and Switzerland on 920 women with EC and 1700 controls. The prevalence of cysts was 5% among both cases and controls, with 63% of cases being overweight/obese. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression models, adjusting for potential confounders. We conducted stratified analyses according to BMI, and estimated the interaction between cysts and BMI; we carried out additional analyses according to age at diagnosis of cysts.ResultsOverall, history of cysts was not associated to EC (OR=1.27, 95% CI=0.82–1.97, P = 0.29). Normal weight women reporting cysts had an increased risk of EC (OR=2.49, 95% CI=1.31–4.74), while no such effect was found among overweight/obese women (OR=0.65, 95% CI=0.36–1.18; P for interaction=0.004). The association was limited to women below 65 years of age and was stronger in those who reported cysts at age 48 or older.ConclusionsCysts appeared to be a risk factor for EC in lean women but not in overweight/obese ones; these results are consistent with an effect of cysts and obesity on EC along common pathways. |
| |
| Keywords: | Endometrial cancer Ovarian cysts BMI Overweight Obesity Effect modification |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
