| 凝溶胶蛋白基因的生物学功能及其应用研究进展 |
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| 引用本文： | 师书玥,李丽娟,寇浩玮,郑立,雷初朝,张禹,钟佳琳,陈宏,黄永震.凝溶胶蛋白基因的生物学功能及其应用研究进展[J].基因组学与应用生物学,2019,38(7):3016-3023. |
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| 作者姓名： | 师书玥 李丽娟 寇浩玮 郑立 雷初朝 张禹 钟佳琳 陈宏 黄永震 |
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| 作者单位： | 西北农林科技大学动物科技学院,杨凌,712100;贵州工程应用技术学院毕节试验区研究院,毕节,551700;河南牧业经济学院动物科技学院,郑州,450046 |
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| 基金项目： | 国家自然科学基金;河南省科技开放合作项目;国家肉牛牦牛产业技术体系项目;陕西省自然科学基础研究计划面上项目;陕西省自然科学基础研究计划面上项目;贵州省科技计划;贵州省教育厅青年科技人才成长项目;大学生创新创业训练计划项目;大学生创新创业训练计划项目;大学生创新创业训练计划项目;大学生创新创业训练计划项目;大学生创新创业训练计划项目 |
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| 摘 要： | 凝溶胶蛋白(gelsolin,GSN)是Gelsolin/Villin超家族的核心成员,是一种多功能的钙依赖性肌动蛋白结合蛋白,在细胞中Ca^2+和PIP2等多因素的调控下,对细胞凋亡、吞噬功能、肌动蛋白微丝切割、细胞信号转导等方面起着重要的作用。近年来,凝溶胶蛋白还被频繁用于相关疾病的预防、诊断与治疗,但其在调控细胞凋亡、炎症等病理生理中的作用机制还存在些许争议。本研究综述了凝溶胶蛋白的结构特点、生物学功能以及对疾病的诊断和治疗,旨在了解凝溶胶蛋白在生物医学及动物科学等领域的应用以及未来凝溶胶蛋白的发展前景。
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| 关 键 词： | 凝溶胶蛋白 肌动蛋白 细胞凋亡 结构特点 生物学功能 |
The Biological Function of the Gelsolin Gene and Its Research Progress |
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| Shi Shuyue,Li Lijuan,Kou Haowei,Zheng Li,Lei Chuzhao,Zhang Yu,Zhong Jialin,Chen Hong,Huang Yongzhen.The Biological Function of the Gelsolin Gene and Its Research Progress[J].Genomics and Applied Biology,2019,38(7):3016-3023. |
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| Authors: | Shi Shuyue Li Lijuan Kou Haowei Zheng Li Lei Chuzhao Zhang Yu Zhong Jialin Chen Hong Huang Yongzhen |
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| Institution: | (College of Animal Science and Technology,Northwest Agriculture and Forestry University,Yangling,712100;Guizhou University of EngineeringScience,Institute of Bijie Test Area,Bijie,551700;College of Animal Science and Technology,Henan University of Animal Husbandry and Economy,Zhengzhou,450046) |
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| Abstract: | Gelsolin(GSN)is a core member of Gelsolin/Villin superfamily,which is a multifunctional calciumdependent actin-binding protein that regulates apoptosis in cells under the control of multiple factors like Ca^2+and PIP2.And it plays an important role in cell apoptosis,phagocytosis,actin filaments cleavage,cell signaling and other aspects.In recent years,gelsolin has also been frequently used in the diagnosis,treatment and prevention of related diseases.However,its mechanism of action in the regulation of apoptosis,inflammation and other pathophysiology is still somewhat controversial.This review summarizes the structural features,biological functions,and diagnosis and treatment of gelsolin in order to understand the status of gelsolin in the fields of biomedicine and animal sciences and the future development of gelsolin. |
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| Keywords: | Gelsolin Actin Cell apoptosis Design feature Biological function |
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