Mallotus philippinensis bark extracts promote preferential migration of mesenchymal stem cells and improve wound healing in mice |
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| Affiliation: | 1. Skin Regeneration, PIAS Collaborative Research, UIC, Osaka University, Japan;2. Research & Development Division, PIAS Corporation, Japan;3. Division of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University, Japan;4. Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Japan;1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, UP, India;2. Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226 001, UP, India;1. Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Mexico;2. Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., Mexico;1. Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil;2. Centro de Ciências da Saúde – Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil;3. Centro de Ciências Biológicas – Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil;1. Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi 324-8501, Japan;2. Advanced Education and Research Center for Kampo Medicine, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi 324-8501, Japan;1. Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India;2. Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India;1. Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China;2. Department of Neurosurgery, Affiliated Bayi Brain Hospital, The Military General Hospital of Beijing PLA, Beijing, China;3. Department of Neurosurgery, First Affiliated Hospital of Jinan University, Guangzhou, China |
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| Abstract: | ![]()
In the present study, we report the effects of the ethanol extract from Mallotus philippinensis bark (EMPB) on mesenchymal stem cell (MSC) proliferation, migration, and wound healing in vitro and in a mouse model. Chemotaxis assays demonstrated that EMPB acted an MSC chemoattractant and that the main chemotactic activity of EMPB may be due to the effects of cinnamtannin B-1. Flow cytometric analysis of peripheral blood mononuclear cells in EMPB-injected mice indicated that EMPB enhanced the mobilization of endogenous MSCs into blood circulation. Bioluminescent whole-animal imaging of luciferase-expressing MSCs revealed that EMPB augmented the homing of MSCs to wounds. In addition, the efficacy of EMPB on migration of MSCs was higher than that of other skin cell types, and EMPB treatment improved of wound healing in a diabetic mouse model. The histopathological characteristics demonstrated that the effects of EMPB treatment resembled MSC-induced tissue repair. Taken together, these results suggested that EMPB activated the mobilization and homing of MSCs to wounds and that enhancement of MSC migration may improve wound healing. |
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| Keywords: | Phenolic compounds Mesenchymal stem cells Migration Wound healing |
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