Essential oil composition of Senecio graciliflorus DC: Comparative analysis of different parts and evaluation of antioxidant and cytotoxic activities |
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| Institution: | 1. Bioorganic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Srinagar 190005, Jammu and Kashmir, India;2. Cancer Pharmacology Division, Indian Institute of Integrative Medicine (CSIR), Jammu 180001, Jammu and Kashmir, India;3. Instrumentation Division, Indian Institute of Integrative Medicine (CSIR), Jammu 180001, Jammu and Kashmir, India;4. Department of Chemistry, University of Kashmir, Srinagar 190006, India;1. Department of Surgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan;3. Department of Hematology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan;1. Medicinal Plant Herbarium, Southern Cross University, PO Box 157, Lismore, NSW 2480, Australia;2. Integria Healthcare, Gallans Road, Ballina, NSW 2478, Australia;3. Southern Cross Plant Science, Southern Cross University, PO Box 157, Lismore, NSW 2480, Australia;1. Unitat de Toxicologia, Departament de Farmacologia, Terapèutica i Toxicologia, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Cerdanyola, Catalonia, Spain;2. RIKILT-Wageningen UR, P.O. Box 230, NL-6700 AE Wageningen, The Netherlands;3. Servei de Ressonància Magnètica Nuclear, Edifici C, Universitat Autònoma de Barcelona, 08193 Cerdanyola, Catalonia, Spain;1. National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, China;2. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China;1. Servicio de Reumatología, Hospital Universitario de la Princesa, IIS-Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain;2. Servicio de Reumatología, Hospital Universitario del Niño Jesús, IIS-Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain |
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| Abstract: | The essential oil of different parts of Senecio graciliflorus DC was obtained by hydrodistillation and analysed by GC-FID and GC–MS for the first time. A total of 17, 20, 19 and 17 constituents were identified comprising 99.90, 95.50, 98.93 and 95.96% of the essential oil of flower, leaf, stem and root parts of Senecio graciliflorus respectively. Monoterpene hydrocarbons predominated in the essential oil with 85.28% in flower, 57.53% in leaf, 67.74% in stem and 64.98% in root oil. α-pinene, cis-ocimene, 1,2,3-trimethylcyclohexane and β-pinene were the major constituents of the essential oil. The flower essential oil exhibited a strong antioxidant potential displaying IC50 values of 21.6 ± 0.6 and 26.0 ± 1.0 μg/ml in DPPH and hydroxyl radical assays respectively. On the other hand the essential oil of flower and root displayed highest cytotoxicity against lung (A-549) cancer cell lines (IC50 = 19.1 ± 0.9 and 21.3 ± 1.1 μg/ml respectively. This study which represents the first report of the essential oil composition and bioevaluation of Senecio graciliflorus, can serve as a new source of cytotoxic and antioxidant activity. |
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| Keywords: | Essential oil Antioxidant Cytotoxicity |
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