The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population |
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| Authors: | Xiaohua Chen Hua Du Binjian Liu Li Zou Wei Chen Yang Yang Ying Zhu Yajie Gong Jianbo Tian Feng Li Shan Zhong |
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| Affiliation: | 1. Department of Medical Genetics, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.; 2. Department of Laboratory Medicine, No 161 Hospital of PLA, Wuhan, 430010, China.; 3. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; 4. Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China.; Beijing University of Chemical Technology, CHINA, |
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| Abstract: | BackgroundAberrant alternative splicing included alterations in components of the mRNA splicing machinery often occurred in colon cancer. However, the role of SF3A1, one key component of the mRNA splicing machinery, on colorectal cancer (CRC) risk was still not elucidated.Method and FindingsWe performed a hospital-based case-control study containing 801 CRC patients and 817 cancer-free controls to examine the association between SF3A1 polymorphisms and CRC risk in a Chinese population. Four candidate SNPs (rs10376, rs5753073, rs2839998 and rs2074733) were selected based on bioinformatics analysis and previous findings. The results showed no significant associations between these SNPs and CRC risk (P > 0.05). Besides, the stratified analysis based on the smoking and alcohol use status obtained no statistically significant results.ConclusionOur study was the first one to investigate the association between SF3A1 polymorphisms and CRC risk. The results suggested these four SNPs in SF3A1 were not associated with CRC risk in a Chinese population, however, further more studies are needed to confirm our findings. |
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