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Microbial transformation of 10-deacetylbaccatin III (10-DAB) by Curvularia lunata and Trametes hirsuta |
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| Authors: | Alberto Arnone Adriana Bava Stefano Alemani Gianluca Nasini Ezio Bombardelli Gabriele Fontana |
| Affiliation: | aCNR-ICRM, Dipartimento di Chimica, Materiali ed Ingegneria Chimica del Politecnico, Via Mancinelli 7, I-20131 Milano, Italy bIndena Spa, Viale Ortles 12, I-20141 Milano, Italy |
| Abstract: | The microbial transformation of 10-deacetylbaccatin III (10-DAB) (1a) and 13-DeBAC (4b) was investigated. Trametes hirsuta induced 13-oxidation of 10-DAB to give (4a) in high yield, whereas incubation with Curvularia lunata resulted in the isolation of the 7-epi-10-DAB (2) and the 7-epi-10-oxo-10-DAB (3). 13-DeBAC (4b) was biotransformed into compounds (4a) and (4c) by Alternaria alternata. |
| Keywords: | Taxanes 10-DAB 13-DeBAC Biotransformations Fungi |
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