Effect of PGE2 on interleukin-1 and superoxide release from primary-cultured human hepatic macrophages. |
| |
| Authors: | N Funaki S Arii Y Adachi H Higashituji S Fujita M Furutani M Mise S Ishiguro T Kitao J Tanaka |
| |
| Institution: | First Department of Surgery, Faculty of Medicine, Kyoto University, Japan. |
| |
| Abstract: | In order to learn more about how human hepatic macrophages function, we analyzed the effect of exogenous PGE2 on the amounts of interleukin-1 (IL-1) and superoxide (O2-) released from primary-cultured human hepatic macrophages (HHM phi). When endogenous PGE2 production was blocked by indomethacin, exogenous PGE2 reduced IL-1 release from HHM phi in a dose-dependent manner, whereas it tended to increase O2- release from HHM phi. These results may suggest the probable contribution of PGE2 in regulating HHM phi mediator release in vivo. |
| |
| Keywords: | |
|
|
