Deletion of the ORF9p Acidic Cluster Impairs the Nuclear Egress of Varicella-Zoster Virus Capsids |
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| Authors: | Laura Riva Marc Thiry Marielle Lebrun Laurent L'homme Jacques Piette Catherine Sadzot-Delvaux |
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| Affiliation: | aUniversity of Liege, GIGA Infection Immunity and Inflammation, Laboratory of Virology and Immunology, Liege, Belgium;bUniversity of Liege, GIGA Neurosciences, Laboratory of Cellular and Tissular Biology, Liege, Belgium;cUniversity of Liege, GIGA Signal Transduction, Laboratory of Virology and Immunology, Liege, Belgium |
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| Abstract: | ![]()
The protein encoded by ORF9 is essential for varicella-zoster virus (VZV) replication. Previous studies documented its presence in the trans-Golgi network and its involvement in secondary envelopment. In this work, we deleted the ORF9p acidic cluster, destroying its interaction with ORF47p, and this resulted in a nuclear accumulation of both proteins. This phenotype results in an accumulation of primary enveloped capsids in the perinuclear space, reflecting a capsid de-envelopment defect. |
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