Status of complete proteome analysis by mass spectrometry: SILAC labeled yeast as a model system |
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| Authors: | Lyris MF de Godoy Jesper V Olsen Gustavo A de Souza Guoqing Li Peter Mortensen Matthias Mann |
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| Institution: | (1) Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz, 82152, Martinsried, Germany;(2) Center for Experimental BioInformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej, 5230, Odense M, Denmark |
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| Abstract: | Background Mass spectrometry has become a powerful tool for the analysis of large numbers of proteins in complex samples, enabling much
of proteomics. Due to various analytical challenges, so far no proteome has been sequenced completely. O'Shea, Weissman and
co-workers have recently determined the copy number of yeast proteins, making this proteome an excellent model system to study
factors affecting coverage. |
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