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E-cadherin deregulation in breast cancer |
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| Authors: | Giovanni Corso Joana Figueiredo Simone Pietro De Angelis Federica Corso Antonia Girardi Joana Pereira Raquel Seruca Bernardo Bonanni Patricia Carneiro Gabriella Pravettoni Elena Guerini Rocco Paolo Veronesi Giacomo Montagna Virgilio Sacchini Sara Gandini |
| Institution: | 1. Division of Breast Surgery, European Institute of Oncology IRCCS, Milan, Italy;2. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal;3. Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy;4. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal Faculty of Medicine, University of Porto, Porto, Portugal;5. Division of Cancer Prevention and Genetics, European Institute of Oncology IRCCS, Milan, Italy;6. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal;7. Department of Oncology and Hemato-Oncology, Faculty of Medicine, University of Milan, Milan, Italy Division of Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology IRCCS, Milan, Italy;8. Department of Oncology and Hemato-Oncology, Faculty of Medicine, University of Milan, Milan, Italy Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy;9. Division of Breast Surgery, European Institute of Oncology IRCCS, Milan, Italy Department of Oncology and Hemato-Oncology, Faculty of Medicine, University of Milan, Milan, Italy;10. Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA;11. Department of Oncology and Hemato-Oncology, Faculty of Medicine, University of Milan, Milan, Italy Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA |
| Abstract: | E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy. |
| Keywords: | breast cancer breast cancer metastases breast cancer prognosis breast cancer survival E-cadherin |