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Identification of Quantitative Trait Loci Controlling Levels of Radiation-Induced Thymocyte Apoptosis in Mice |
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| Authors: | Michael M. Weil Xueqing Xia Yue Lin L.Clifton Stephens Christopher I. Amos |
| Affiliation: | aDepartment of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030-4095;bDepartment of Veterinary Medicine and Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030-4095;cDepartment of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030-4095 |
| Abstract: | Thymocyte apoptosis levels are higher in C57BL/6J mice than in C3Hf/Kam mice. Low-dose irradiation increases the numbers of thymocytes undergoing apoptosis, but the strain difference persists. We mapped three loci controlling radiation-induced thymocyte apoptosis levels in F2 intercross progeny of these strains. The strongest association of a genomic region with an apoptosis level occurred in a region of chromosome 11 known to harbor a locus (or loci) important in the pathogenesis of several rodent models of autoimmune disease. Additional loci influencing radiation-induced thymocyte apoptosis were identified on chromosomes 9 and 16. The genetic polymorphisms underlying these loci may have an evolutionary role in fine-tuning the apoptotic response in T cells and may be important in the etiology of lymphoproliferative disorders and autoimmunity. |
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