蛋白质折叠速率预测研究进展

蛋白质折叠速率预测是当今生物物理学最具挑战性的课题之一。近年来,该领域的研究取得了很大的进展,提出了许多经验参数,例如:接触序、长程序、总接触距离、链拓扑参数、二级结构含量、有效长度、螺旋参数、n-阶接触距离等。这些参数都和蛋白质的折叠速率有很好的相关性,基于这些参数的各种预测方法所得到的预测结果也与实验数据较好地吻合。

Progress in Protein Folding Rate Prediction

Protein-folding rate prediction is one of the most important challenges in contemporary biophysics,and a great progress has been made in the past few years.Many empirical parameters have been proposed successively,such as contact order,long-range order,total contact distance,chain topology parameter,secondary structure content,effective length,helix parameter,n-order contact distance,etc.All of them have significant correlations with protein folding rates.The predicted results by the methods based on these parameters fit well with the experimental folding rates.