Genetic control of the immune response in mice: V. Minor genes involved in the response to H-Y and Ea-1 antigens |
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Authors: | David L Gasser Donald C Shreffler |
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Institution: | 1. Department of Human Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 2. Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan
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Abstract: | Murine responses to both the male specific histocompatibility antigen H-Y and the erythrocyte alloantigen Ea-1 are regulated by genetic factors. In each case a single major gene that controls the immune response has been identified, but additional modifying factors can be demonstrated if appropriate strain combinations are studied. A single gene controlling the response to Ea-1 antigens, which segregates when strains YBR and B10.D2 are crossed, has been shown not to be an allele of theIr-2 locus. A new phenomenon has also been observed in the control of anti-Ea-1 antibody production in that the mating of two responding strains, YBR and HTG, produces an F1 generation of complete nonresponders. By linkage tests it was shown that the responding strain HTG possesses the nonresponder allele at theIr- 2 locus, so there appear to be recessive genes in the background which are able to overcome the suppressive influence of this allele. |
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