Effects of estradiol and progesterone on uterine prostaglandin levels in the pregnant rat |
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Authors: | Laird Wilson Jr |
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Institution: | Department of Obstetrics and Gynecology, University of Illinois at the Medical Center, Chicago, Illinois 60612, USA |
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Abstract: | Prostaglandin D2 was found to be a potent inhibitor of B-16 melanoma cell replication . The inhibition was dose-dependent between 3×10?9M and 3×10?6M (IC50~ 0.3 μM after 6 days). On a molar basis, PGD2 was a better inhibitor than PGA2 or 16,16-dimethyl-PGE2-methyl ester (di-M-PGE2) and in higher concentrations (10?6?10?7M), comparable to retinoic acid. In higher concentrations, PGD2 inhibited DNA, RNA and protein synthesis. The B-16 melanoma cell line which we used synthesized arachidonic acid metabolites which comigrated with PGA2, PGD2, PGE2 and PGF2α on a thin layer chromatography system. |
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Keywords: | Reprint Requests: Dr Laird Wilson Jr Department of Obstetrics and Gynecology University fo Illinois at the Medical Center 840 South Wood Street Chicago Illinois 60612 |
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