The molecular biology of human herpesvirus-6 latency and telomere integration |
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| Authors: | Arbuckle Jesse H Medveczky Peter G |
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| Affiliation: | Department of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA. |
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| Abstract: | The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host. |
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