Two New Amides from Physochlainae Radix |
| |
| Authors: | Jin-Yan Tan Jian-Li Li Pei Li Lu Zhang Yan-Gang Cheng Yan Wang Xiao-Nan Ma Xu-Liang Hao Ying-Li Wang |
| |
| Institution: | 1. Shanxi Modern Chinese Medicine Engineering Laboratory, Shanxi University of Chinese Medicine, Jinzhong, 030619 P. R. China;2. The Affiliated Hospital of Shanxi University of Chinese Medicine, Taiyuan, 030024 P. R. China;3. School of Pharmacy, Shanxi Medical University, Jinzhong, 030600 P. R. China |
| |
| Abstract: | In this article, two undescribed amides ( 1 – 2 ) with an unusual (2-formyl-5-hydroxymethyl)pyrroyl-butylamine moiety were obtained from the Physochlainae Radix. Comprehensive spectroscopic studies, including NMR and HR-ESI-MS, coupling with spectroscopic data comparisons were used to determine structures. Anti-inflammatory assay results showed that new amides possessed significant inhibitory activities of the NO production of LPS-induced RAW 264.7 cells, with IC50 values of 17.52±1.68 μM and 20.37±2.42 μM, respectively. |
| |
| Keywords: | Solanaceae Physochlaina infundibularis amides anti-inflammatory activities chemical composition |
|
|
