Inhibition of rabbit skeletal muscle phosphorylase phosphatase by spermine |
| |
| Authors: | Chiharu Nakai Walter Glinsmann |
| |
| Affiliation: | (1) Section on Physiological Controls, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, 20014 Bethesda, Maryland, USA |
| |
| Abstract: | Summary The effect of three naturally occurring polyamines (putrescine, spermidine, and spermine) on the activity of rabbit skeletal muscle phosphorylase phosphatase was investigated. Only spermine significantly inhibited the enzyme. The mode of inhibition (Ki value of 0.3mm) of the phosphatase by spermine appears to be different from that caused by divalent metal ions or by other organic cations, such as arginine and lysine esters, since it is noncompetitive with respect to the substrate, phosphorylasea. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
