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Prostaglandin E antagonist activity of 11-deoxy-16,16-trimethyleneprostaglandin E1 |
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| Authors: | J E Birnbaum E L Tolman |
| Abstract: | 11-Deoxy-16,16-trimethyleneprostaglandin E1 is a potent inhibitor of prostaglandin E-induced contractions of the gerbil colon. The antagonism is directed specifically against the prostaglandin E receptor and is not manifested when contractions are induced by either prostaglandin F2 alpha or acetylcholine. |
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