A simple method for detecting drug effects on the DNA of mammalian cells |
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| Authors: | B Marshall R K Ralph |
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| Affiliation: | Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 USA |
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| Abstract: | A simple method for detecting drug or X-ray effects on the DNA of intact cells is described. This method uses an easily constructed viscometer to measure changes in the viscosity of alkaline cell lysates. The method has been tested by comparing the effects of 4′-[(9-acridinyl)amino]methanesulfon-o-anisidide (oAMSA), 4′-[(9-acridinyl)amino]methanesulfon-m-anisidide (mAMSA), daunorubicin, and adriamycin on cellular DNA. |
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