Fine-structural localization of neuropeptide tyrosine (NPY)-like immunoreactivity in the neuronal somata of colchicine-pretreated celiac ganglia of rats |
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| Authors: | Dr Hisatake Kondo Hirofumi Kuramoto Miyuki Yamamoto |
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| Institution: | (1) Department of Anatomy, School of Medicine Kanazawa University, Kanazawa, Japan;(2) Department of Anatomy, School of Medicine Niigata University, Niigata, Japan;(3) Department of Anatomy, School of Medicine, Kanazawa University, 920 Kanazawa, Japan |
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| Abstract: | Summary In colchicine-pretreated cells of sympathetic ganglia, intensely NPY-immunoreactive material was localized within vacuoles and vesicles of the disorganized, widely dispersed Golgi apparatus. Intensely positive large granular vesicles, which are known to be one of major storage sites of various peptides in the autonomic nerve endings, were essentially unobserved in the perikaryal cytoplasm. The present finding provides evidence that one pool of NPY-like immunoreactivity is localized in the Golgi apparatus of colchicine-pretreated as well as normal sympathetic ganglion cells. It is also clear that visualization of NPY-immunoreactive somata by colchicine-pretreatment in the sympathetic ganglia is due to the accumulation of the neuropeptide in the disorganized Golgi stacks instead of increased amount of the large granular vesicles containing NPY. |
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| Keywords: | Neuropeptide Intracellular localization Sympathetic ganglia Colchicine Rat |
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