| 可降解组织工程血管支架成功用于犬股动脉移植 |
| |
| 引用本文： | 武欣,谷涌泉,段红永,陈兵,李建新,吴英锋,张淑文,汪忠镐,张建.可降解组织工程血管支架成功用于犬股动脉移植[J].中国实验动物学报,2011,19(3):250-254,279. |
| |
| 作者姓名： | 武欣 谷涌泉 段红永 陈兵 李建新 吴英锋 张淑文 汪忠镐 张建 |
| |
| 作者单位： | 首都医科大学宣武医院血管外科,北京,100053 |
| |
| 基金项目： | 国家高技术研究发展计划(863计划)项目，北京市自然科学基金项目 |
| |
| 摘 要： | 目的采用可降解的聚己内酯接枝肝素材料,负荷b-FGF(碱性成纤维细胞生长因子),体外构建的小口径组织工程血管,完成犬的股动脉移植动物实验。方法利用可降解的聚己内酯接枝肝素材料,电纺丝技术制备组织工程血管支架,并对支架负荷b-FGF生长因子,并进行材料的内皮细胞粘附实验。将体外构建的小口径组织工程血管,完成犬的股动脉移植动物实验,观察通畅率和移植术后组织工程血管的改变。结果可降解聚己内酯接枝肝素材料支架,负荷细胞生长因子(b-FGF),利于内皮细胞粘附。构建的组织工程血管进行体外动物实验构建,3个月移植物通畅率好,移植后取材,有新生内膜迁移和胶原纤维浸入。结论利用可降解聚己内酯接枝肝素材料构建小口径支架,初步符合构建组织工程血管支架的要求。
|
| 关 键 词： | 可降解聚己内酯材料 血管支架 组织工程 抗凝 股动脉移植 通畅性 犬 |
Successful application of biodegradable vascular scaffolds in the dog femoral artery transplantation |
| |
| WU Xin,GU Yong-quan,DUAN Hong-yong,CHEN Bing,LI Jian-xin,WU Ying-feng,ZHANG Shu-wen,WANG Zhong-gao,ZHANG Jian.Successful application of biodegradable vascular scaffolds in the dog femoral artery transplantation[J].Acta Laboratorium Animalis Scientia Sinica,2011,19(3):250-254,279. |
| |
| Authors: | WU Xin GU Yong-quan DUAN Hong-yong CHEN Bing LI Jian-xin WU Ying-feng ZHANG Shu-wen WANG Zhong-gao ZHANG Jian |
| |
| Institution: | WU Xin,GU Yong-quan,DUAN Hong-yong,CHEN Bing,LI Jian-xin,WU Ying-feng,ZHANG Shu-wen,WANG Zhong-gao,ZHANG Jian(Department of Vascular Surgery,Xuan Wu Hospital,Capital University of Medical Sciences,Beijing 100053,China) |
| |
| Abstract: | Objective To investigate the feasibility of heparin-bonded biodegradable polycaprolactone(PCL) materials in animal femoral artery transplantation.Methods Heparin-bonded biodegradable PCL materials loaded with basic fibroblast growth factor(b-FGF) were used as vascular tissue engineering scaffold,and small-diameter tubular scaffolds for tissue engineering blood vessel were constructed using electrospinning technique.Endothelial cell adhesion experiment was conducted to evaluate the adhesion of endothelial ce... |
| |
| Keywords: | Biodegradable polycaprolactone(PCL) materials Vascular scaffold Tissue engineering Anticoagulation Femoral artery transplantation Patency rate Dog |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
