Cellular immunity in pyelonephritis: inhibition of the spleen cell response to the mitogen concanavalin A |
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| Authors: | T W Williams A M Friedlander J M Lyons A I Braude |
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| Institution: | The Departments of Medicine and Pathology, School of Medicine, University of California in San Diego, San Diego, California, 92103 U.S.A. |
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| Abstract: | Spleen cells from rats given experimental pyelonephritis using Escherichia coli and Proteus mirabilis as infecting organisms were evaluated for their ability to respond to the mitogen Concanavalin A. Results indicate an 80% reduction in the response of animals with gross suppuration in the kidney, but no inhibition is observed in animals with kidney infection, but not renal abscesses. The inhibition is not, apparently, due to serum factors. |
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