缺氧预适应研究的进展与展望

缺氧预适应这一生物进化上的内源性细胞保护机制,可被机体、器官、组织和细胞的重复缺氧暴露所激发。缺氧预适应的效应已由对重复缺氧局部／原位器官组织的保护（局部／原位缺氧预适应）发展到既保护远隔的各种异位器官组织（远程／异位缺氧预适应）又抗御其它种种非缺氧性应激（交叉／多能缺氧预适应）。在现有进展的基础上,缺氧预适应研究以及其可操作性和可应用性将有更大的发展空间。

Progresses of prospects for hypoxic preconditioning

Hypoxic preconditioning (HPC), a strategy of intrinsic cytoprotection developed in biological evolution, is designed to be motivated by repetitive exposure of organism, organ, tissue and cell to condition of hypoxia. The effect of HPC is broadened remotely to protect different organ-tissues in other regions ( remote/ectopic HPC, r/e HPC ) and crossly to resist a variety of stresses other than hypoxia ( cross/pluripotential HPC, c/pHPC ) from protection of original local in situ organ-tissue repeatedly exposed to hypoxia ( local/in situ HPC, l/Ii HPC). More spaces for development of feasibility and applicability in the research on HPC would be expected based on the progresses recently available.