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Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications |
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| Authors: | Liubov A Osminkina Konstantin P Tamarov Andrey P Sviridov Rostislav A Galkin Maxim B Gongalsky Valery V Solovyev Andrey A Kudryavtsev Victor Yu Timoshenko |
| Institution: | 1. Lomonosov Moscow State University, Department of Physics, 119992 Moscow, Russia;2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushino, 142290 Moscow region, Russia;3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushino, 142290 Moscow region, RussiaPhone: +007 4967 739 348, Fax: +007 4967 739 348 |
| Abstract: | Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization of living cells in vitro. It was found that SiNPs could penetrate into the cells without any cytotoxic effect up to the concentration of 100 μg/ml. The cell cytoplasm was observed to be filled by SiNPs, which exhibited bright photoluminescence at 1.6 eV. SiNPs could also act as photosensitizers of the singlet oxygen generation, which could be used in the photodynamic therapy of cancer. These properties of SiNPs are discussed in view of possible applications in theranostics (both in therapy and in diagnostics). (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
| Keywords: | silicon nanoparticles porous silicon bio‐imaging biocompatible theranostics of cancer |