Long-range regulation is a major driving force in maintaining genome integrity |
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| Authors: | Emmanuel Mongin Ken Dewar Mathieu Blanchette |
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| Institution: | (1) McGill Centre for Bioinformatics, McGill University, Montreal, Canada;(2) Research Institute of McGill University Health Centre, McGill University and Genome Quebec Innovation Centre, Montreal, Canada;(3) Departments of Human Genetics and Experimental Medicine, McGill University, Montreal, Canada;(4) School of Computer Science, McGill University, Montreal, Canada |
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| Abstract: | Background The availability of newly sequenced vertebrate genomes, along with more efficient and accurate alignment algorithms, have
enabled the expansion of the field of comparative genomics. Large-scale genome rearrangement events modify the order of genes
and non-coding conserved regions on chromosomes. While certain large genomic regions have remained intact over much of vertebrate
evolution, others appear to be hotspots for genomic breakpoints. The cause of the non-uniformity of breakpoints that occurred
during vertebrate evolution is poorly understood. |
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