High levels of urinary midkine in various cancer patients |
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Authors: | Ikematsu Shinya Okamoto Kohji Yoshida Yoshihiro Oda Munehiro Sugano-Nagano Hitomi Ashida Kinya Kumai Hideshi Kadomatsu Kenji Muramatsu Hisako Takashi Muramatsu Sakuma Sadatoshi |
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Institution: | Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan. |
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Abstract: | Midkine (MK) is a heparin-binding growth factor, which promotes growth, migration, and survival of various cells, and MK expression is increased in many human carcinomas. We determined the urinary MK level by enzyme-linked immunoassay. Taking 311pg/mg creatinine as a cut-off level, 70% of patients with various carcinomas (n=142) gave positive values, while only 5.5% of healthy volunteers (n=330) did. In case of gastric carcinoma, 17 out of 21 patients with stage 1 tumor were positive. Urinary MK levels are expected to become a convenient marker as an aid in detection of tumors. |
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Keywords: | Midkine Tumor marker Enzyme-linked immunoassay Urine |
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