Brain-derived neurotrophic factor shows a protective effect and improves recovery of the ERG b-wave response in light-damage |
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Authors: | Ikeda Kazuhito Tanihara Hidenobu Tatsuno Tohru Noguchi Hiroshi Nakayama Chikao |
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Institution: | Sumimoto Pharmaceuticals Research Division, Osaka, Japan. ikedak@sumimotopharm.co.jp |
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Abstract: | We investigated the neuroprotective effects of brain-derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light-induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned to a cyclic light environment for 14 days. The result indicated that BDNF had few effects on the a-wave amplitude, but there was a statistically significant difference in the b-wave amplitudes between BDNF-treated and control eyes from day 0-14 of the recovery period following 2 days of light exposure (p < 0.05). Our findings suggest that BDNF not only protects the retinal neuronal function but also enhances the recovery from retinal light damage. |
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Keywords: | brain-derived neurotrophic factor electroretinogram neuroprotection neurotrophins photoreceptor retinal damage |
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