Metabolic engineering of microbial pathways for advanced biofuels production |
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Authors: | Zhang Fuzhong Rodriguez Sarah Keasling Jay D |
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Institution: | 1Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA;2Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA;3Joint BioEnergy Institute, 5885 Hollis Street, Emeryville, CA 94608, USA;4Synthetic Biology Engineering Research Center, 5885 Hollis Street, Emeryville, CA 94608, USA;5Physical Bioscience Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA |
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Abstract: | Production of biofuels from renewable resources such as cellulosic biomass provides a source of liquid transportation fuel to replace petroleum-based fuels. This endeavor requires the conversion of cellulosic biomass into simple sugars, and the conversion of simple sugars into biofuels. Recently, microorganisms have been engineered to convert simple sugars into several types of biofuels, such as alcohols, fatty acid alkyl esters, alkanes, and terpenes, with high titers and yields. Here, we review recently engineered biosynthetic pathways from the well-characterized microorganisms Escherichia coli and Saccharomyces cerevisiae for the production of several advanced biofuels. |
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