Novel cytotoxic chalcones from Litsea rubescens and Litsea pedunculata |
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| Authors: | Li Liang Zhao Xing-Tang Luo Yi-Ping Zhao Jing-Feng Yang Xiao-Dong Zhang Hong-Bing |
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| Institution: | aKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China;bYunnan Hongxiang Yixin Hall Pharmaceutical Co., Ltd, Kunming 650106, PR China;cThe Faculty of Life Sciences, Simao Teachers’ College, Simao 665000, PR China |
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| Abstract: | Two novel flavonoids with chalcone skeleton, together with seven known flavonoids, were isolated from the stem barks of Litsea rubescens and Litsea pedunculata. The structures of the new compounds were elucidated on the basis of spectral methods including IR, UV, 1D and 2D NMR. The new chalcones were found to contain the rare epoxy or ethylidenedioxy group. This is the first report on the presence of chalcone in the plant genus Litsea. The cytotoxic potential of two new chalcones was evaluated in vitro against three human tumor cell lines. Both new chalcones displayed potent cytotoxic activities against myeloid leukaemia (HL-60) and epidermoid carcinoma (A431) cell lines and more active than cisplatin (DDP). Interestingly, compound 1 exhibited cytotoxic activity against HL-60 with IC50 value 2.1-fold more sensitive to DDP. |
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| Keywords: | Chalcone Flavonoid Litsea rubescens Litsea pedunculata Cytotoxic activities |
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