Alternate-day fasting protects the rat heart against age-induced inflammation and fibrosis by inhibiting oxidative damage and NF-kB activation |
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| Authors: | Laura Castello Teresa Froio Marco Maina Gabriella Cavallini Fiorella Biasi Gabriella Leonarduzzi Alessio Donati Ettore Bergamini Giuseppe Poli Elena Chiarpotto |
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| Institution: | 1. Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;2. Department Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;3. Department Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;4. Quality Assurance Unit, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;2. School of Pharmacy, Sungkyunkwan University, Suwon, South Korea;3. Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA;4. Department of Physiology, Georgia Health Sciences University, Augusta, GA, USA;5. School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia;1. Faculdade de Medicina, Universidade Federal do Cariri, Barbalha, CE, Brazil;2. Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil |
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| Abstract: | The free radical theory of aging is currently one of the most popular. In parallel, many studies have demonstrated the association of fibrosis and increased oxidative stress in the pathogenesis of some chronic human diseases, and fibrosis is often characteristic of aging tissues. One of the few interventions that effectively slow aging is calorie restriction and the protection against the age-associated increase of oxidative stress remains one of the foremost hypotheses to explain this action. As an alternative to traditional calorie restriction, another dietary regimen, termed alternate-day fasting, has also been tested, whose antiaging mechanisms have not been explored so much extensively. We thus studied the effects of alternate-day fasting, started at 2 months of age, on oxidative stress and fibrosis in the heart during aging. In the left ventricle of the heart of elderly (aged 24 months) versus young (aged 6 months) male rats we found a significant increase in oxidative stress paralleled by increased fibrosis. In parallel there was a significant increase in inflammatory cytokine levels and in NF-kB DNA binding activity with advancing age. Alternate-day fasting protected against all these age-related phenomena. These data support the hypothesis that this kind of dietary restriction protects against age-related fibrosis, at least in part by reducing inflammation and oxidative damage, and this protection can thus be considered a factor in the prevention of age-related diseases with sclerotic evolution. |
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