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Studies on a possible pituitary effect of monoamines on luteinizing hormone release in ovariectomized rats
Authors:K Ryu  J A Williams  R V Gallo
Institution:Department of Physiology University of California School of Medicine San Francisco, California 94143, USA
Abstract:Incubation of anterior pituitaries from ovariectomized rats with LHRH and various concentrations of dopamine, norepinephrine or serotonin indicated that none of these neurotransmitters could decrease pituitary LH secretion in response to the releasing hormone. This indicated that the inhibitions of pulsatile LH release previously observed in our laboratory in ovariectomized rats in response to intraventricularly administered catecholamines or stimulation of brain serotoninergic neurons are due to central rather than pituitary effects of these transmitters.
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