Activity of glucose-6-phosphate dehydrogenase in sea urchin embryos of different developmental trends |
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| Affiliation: | 1. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore;2. Lee Kong Chian School of Medicine, Nanyang Technological University, Academia, 20 College Road, 169856, Singapore;3. Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Agency for Science Technology & Research, 138673, Singapore;4. KK Research Centre, KK Women''s and Children''s Hospital, 100 Bukit Timah Road, 229899, Singapore;5. Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Pediatric Research Institute-Hospital Sant Joan de Déu, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain;6. INRA ToxAlim, UMR1331, Chemin de Tournefeuille, Toulouse Cedex 3, France;7. Center for Integrative Genomics, University of Lausanne, Le Génopode, CH 1015 Lausanne, Switzerland;1. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan;2. Department of General and Gastroenterological Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan;3. Department of Gastroenterology, Fujita Health University, School of Medicine, 1-98 Dengakugakubo Kutsukake-cho, Toyoake, Aichi 470-1192, Japan;4. Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan |
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| Abstract: | The relative activity of glucose-6-phosphate dehydrogenase has been determined in a large number of stages and in different trends of development of the sea urchin egg.The activity is found to increase rapidly immediately after fertilization in Paracentrotus, or some hours later in Psammechinus. Two individual peaks in activity are reached, one at the late cleavage stage, the other after hatching. In later stages, a stepwise decrease is found to occur. Before hatching, larvae with hypertrophied ectoderm or entoderm show a similar pattern in enzyme activity as normal larvae. After hatching, animalized larvae are found to have a higher enzyme level than vegetalized larvae.The role of the enzyme activity in the processes of determination and differentiation is discussed against the background of these observations. It is concluded that the enzyme activity can be regarded as a measure of the shunt activity. The relation between enzyme activity and reduction gradients is also discussed. |
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