Novel metabolic pathway for salicylate biodegradation via phenol in yeast Trichosporon moniliiforme |
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Authors: | Yuichiro Iwasaki Hiroaki Gunji Kuniki Kino Takasumi Hattori Yoshitaka Ishii Kohtaro Kirimura |
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Affiliation: | (1) Faculty of Science and Engineering, Department of Applied Chemistry, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan; |
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Abstract: | A novel metabolic pathway was found in the yeast Trichosporon moniliiforme WU-0401 for salicylate degradation via phenol as the key intermediate. When 20 mM salicylate was used as the sole carbon source for the growth of strain WU-0401, phenol was detected as a distinct metabolite in the culture broth. Analysis of the products derived from salicylate or phenol through reactions with resting cells and a cell-free extract of strain WU-0401 indicated that salicylate is initially decarboxylated to phenol and then oxidized to catechol, followed by aromatic ring cleavage to form cis-cis muconate. |
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