The effect of oxidized dextrans on generation of reactive oxygen species by murine peritoneal exudate phagocytes |
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| Authors: | V O Tkachev M V Zaikovskaya A V Troitsky N G Luzgina V A Shkurupy |
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| Institution: | 1.Research Center of Clinical and Experimental Medicine Siberian Branch of Russian Academy of Medical Sciences,Novosibirsk,Russia |
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| Abstract: | The effects of oxidized dextrans of different molecular masses on reactive oxygen species production and mitochondrial transmembrane
potential of macrophages and neutrophils have been studied in vivo and in vitro. Oxidized dextrans demonstrated moderate direct
antioxidant properties but induced intracellular oxidative stress through the increase of oxygen radical generation. This
effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and in addition it can
influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases. |
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