Allergen mimotopes |
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Authors: | Riemer Angelika Scheiner Otto Jensen-Jarolim Erika |
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Affiliation: | Institute of Pathophysiology, General Hospital Vienna, University of Vienna, Leitstelle 3Q, Vienna 1090, Austria. |
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Abstract: | The causative treatment of type I allergies is a long pursued goal in immunology. To design safe and efficient vaccine preparations, the interaction of the allergen and the symptom-inducing IgE antibodies still needs to be better understood. In this article, we describe the use of the phage display technique in allergy. It yields epitope mimics, so-called mimotopes, which can be employed for both, investigation of allergen-IgE interactions and definition of safe novel vaccines. |
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