利用油体表达系统生产外源重组蛋白的研究进展

植物生产外源蛋白日益受到重视，是一个安全廉价的生产系统。植物油体表达系统利用油素蛋白的高表达性和易分离特性改进了植物生物反应器下游加工技术、降低了高纯度药用蛋白的生产成本。本文介绍了油体和油素蛋白的组成结构等特征，重点阐述了国内外各领域用植物油体表达系统生产外源蛋白的研究进展，探讨了油体系统的优势和存在的问题。本实验室利用油体系统开发酸性成纤维细胞生长因子(haFGF)医类新药，生物活性检测正在进行中。油体表达系统作为药用蛋白的新来源，将得到逐步的完善及更广泛的应用。

Development on Plant Seed Oil Body Expression System for Recombinant Proteins Production

Plant transgenic system secures a safe,economical and reliable supply of recombinant proteins.Plant oilbody expression system simplifies the downstream purification steps and reduces capital investment based on the nature of oleosin including high expression and easy extraction.The structures and characteristics of seed oil body and oleosin were reviewed.And the research progress and industry of the seed oil body expression system,as a new bioreactor,to produce valuable recombinant proteins were discussed.The benefits and questions of the oil body expression system were also set forth.New medicine haFGF based on the oilbody system is being developed,and its biological activity is being analyzed.As a new resource for medicine protein,oilbody expression system will be perfected and applied broadly.