Thiophene containing triarylmethanes as antitubercular agents |
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| Authors: | Parai Maloy Kumar Panda Gautam Chaturvedi Vinita Manju Y K Sinha Sudhir |
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| Institution: | Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India. |
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| Abstract: | A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37R(v) and showed the activity in the range of 3.12-12.5 microg/mL in vitro. |
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