|
|||||
|
|
On the role of mi-cK and VDAC in mitochondrial function of heart muscle cells |
|
| Authors: | ter Veld Frank Bruggeman Frank Jeneson Jeroen Nicolay Klaas |
| Affiliation: | (1) Dept. of Experimental In-Vivo NMR, Image Sciences Institute, UMC, Utrecht;(2) Dept. of Molecular Cell Physiology, Faculty of Biology, Free University, Amsterdam;(3) Dept. of Physiology, School of Veterinary Medicine, University of Utrecht, The Netherlands |
| Abstract: | A two-compartment kinetic model was used to describe reconstituted systems in which mitochondria compete with pyruvate kinase for kinase-generated ADP. The modelling suggests that cytosolic CK deficiency results in a 50% increase in outer mitochondrial membrane permeability. |
| Keywords: | Creatine kinase Oxidative phosphorylation Mitochondria Compartmentation Modelling |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |